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题名:
Imaging and force recognition of single molecular behaviors using atomic force microscopy
作者: Li M(李密); Dang D(党丹); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超)
作者部门: 机器人学研究室
通讯作者: 刘连庆 ; 席宁
关键词: atomic force microscopy ; single-molecule ; topography ; mechanics ; molecular recognition
刊名: Sensors (Switzerland)
ISSN号: 1424-8220
出版日期: 2017
卷号: 17, 期号:1, 页码:1-20
收录类别: SCI ; EI
产权排序: 1
项目资助者: National Natural Science Foundation of China (61503372, 61522312, 61327014, 61433017), the Youth Innovation Promotion Association CAS (No. 2017243), and the CAS FEA International Partnership Program for Creative Research Teams.
摘要: The advent of atomic force microscopy (AFM) has provided a powerful tool for investigating the behaviors of single native biological molecules under physiological conditions. AFM can not only image the conformational changes of single biological molecules at work with sub-nanometer resolution, but also sense the specific interactions of individual molecular pair with piconewton force sensitivity. In the past decade, the performance of AFM has been greatly improved, which makes it widely used in biology to address diverse biomedical issues. Characterizing the behaviors of single molecules by AFM provides considerable novel insights into the underlying mechanisms guiding life activities, contributing much to cell and molecular biology. In this article, we review the recent developments of AFM studies in single-molecule assay. The related techniques involved in AFM single-molecule assay were firstly presented, and then the progress in several aspects (including molecular imaging, molecular mechanics, molecular recognition, and molecular activities on cell surface) was summarized. The challenges and future directions were also discussed.
语种: 英语
EI收录号: 20170503301801
WOS记录号: WOS:000393021000199
WOS标题词: Science & Technology ; Physical Sciences ; Technology
类目[WOS]: Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
关键词[WOS]: HIGH-SPEED AFM ; DYNAMIC BIOMOLECULAR PROCESSES ; MEMBRANE-PROTEINS ; CELL-SURFACE ; LIVING CELLS ; CANCER-CELLS ; IN-VIVO ; BIOPHYSICAL PROPERTIES ; MECHANICAL-PROPERTIES ; FUNCTIONAL-ANALYSIS
研究领域[WOS]: Chemistry ; Electrochemistry ; Instruments & Instrumentation
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内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/19888
Appears in Collections:机器人学研究室_期刊论文

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Recommended Citation:
Li M,Dang D,Liu LQ,et al. Imaging and force recognition of single molecular behaviors using atomic force microscopy[J]. Sensors (Switzerland),2017,17(1):1-20.
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