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Modular and Customized Fabrication of 3D Functional Microgels for Bottom-Up Tissue Engineering and Drug Screening
Yang WG(杨文广)1; Cai, Shuxiang1; Chen, Yibao1; Liang WF(梁文峰)2; Lai YB(来佑彬)3; Yu HB(于海波)4; Wang YC(王越超)4; Liu LQ(刘连庆)4
Department机器人学研究室
Source PublicationADVANCED MATERIALS TECHNOLOGIES
ISSN2365-709X
2020
Pages1-7
Indexed BySCI ; EI
EI Accession number20200908247823
WOS IDWOS:000517404600001
Contribution Rank4
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China [61973224, 61803323, 51605311] ; Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2019BF049]
Keyworddrug screening microgels optofluidic maskless lithography tissue engineering
Abstract

Customized generation of 3D functional building blocks is crucial for bottom-up tissue engineering. Currently, high throughput production, high survival rates, and well-controlled shapes are considered as three major challenges in fabricating microgels. Here, an optofluidic maskless lithography system that combines digital micromirror device based 3D printing and microfluidic technologies for fabricating 3D functional microgels, is presented. With this system, 3D microgels can be custom designed online and manufactured modularly in a microfluidic device. The fabrication process is based on shadowed light, highly flexible, and requires no physical masks. Furthermore, cells in microgels exhibit features that are more similar to the complex in vivo conditions, including morphology, proliferation, and drug resistance.

Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/26438
Collection机器人学研究室
Corresponding AuthorYang WG(杨文广); Yu HB(于海波); Liu LQ(刘连庆)
Affiliation1.School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China
2.School of Mechanical Engineering, Shenyang Jianzhu University, Shenyang 110016, China
3.College of Engineering, Shenyang Agricultural University, Shenyang 110016, China
4.State Key Laboratory of Robotics, Shenyang Institute of Automation, Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110016, China
Recommended Citation
GB/T 7714
Yang WG,Cai, Shuxiang,Chen, Yibao,et al. Modular and Customized Fabrication of 3D Functional Microgels for Bottom-Up Tissue Engineering and Drug Screening[J]. ADVANCED MATERIALS TECHNOLOGIES,2020:1-7.
APA Yang WG.,Cai, Shuxiang.,Chen, Yibao.,Liang WF.,Lai YB.,...&Liu LQ.(2020).Modular and Customized Fabrication of 3D Functional Microgels for Bottom-Up Tissue Engineering and Drug Screening.ADVANCED MATERIALS TECHNOLOGIES,1-7.
MLA Yang WG,et al."Modular and Customized Fabrication of 3D Functional Microgels for Bottom-Up Tissue Engineering and Drug Screening".ADVANCED MATERIALS TECHNOLOGIES (2020):1-7.
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