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Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces
Yang WG(杨文广)1; Sun LJ(孙路静)1; Cai, Shuxiang1; Chen, Yibao1; Liang WF(梁文峰)2; Zhou PL(周培林)3,4; Yu HB(于海波)3,4; Wang YC(王越超)3,4; Liu LQ(刘连庆)3,4
Department机器人学研究室
Source PublicationLAB ON A CHIP
ISSN1473-0197
2020
Volume20Issue:14Pages:2447-2452
Indexed BySCI ; EI
EI Accession number20203008979841
WOS IDWOS:000548638600015
Contribution Rank3
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China [61973224, 61803323] ; Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2019BF049]
Abstract

Cell adhesion plays an important role in cell communication, organ formation and tissue maintenance. Spatial microstructure patterning has the capability to regulate cell functions such as cell adhesion and cell proliferation as well as cellular mechanical properties. In this study, we present a simple method to fabricate micro-hump patterned interfaces based on electrohydrodynamic jet (E-jet) printing to control and direct cell organization. Micro-hump structures were rapidly fabricated by E-jet printing and arbitrary cell patterns can be achieved by selective cell adhesion induced by this surface topography. Furthermore, cellular mechanical properties were regulated by changing the density of microstructures. The technique we proposed could dynamically direct cell organization in a controlled manner, providing help for exploring the fundamental mechanism of cell adhesion and sensing.

Language英语
WOS SubjectBiochemical Research Methods ; Chemistry, Multidisciplinary ; Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation
WOS KeywordSTEM-CELL ; SUBSTRATE MICROTOPOGRAPHY ; MECHANICAL-PROPERTIES ; ADHESION ; TOPOGRAPHY ; SURFACE ; DIFFERENTIATION ; PROLIFERATION ; MIGRATION ; RESPONSES
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation
Funding ProjectNational Natural Science Foundation of China[61973224] ; National Natural Science Foundation of China[61803323] ; Natural Science Foundation of Shandong Province[ZR2019BF049]
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/27372
Collection机器人学研究室
Corresponding AuthorYang WG(杨文广); Yu HB(于海波); Liu LQ(刘连庆)
Affiliation1.School of Electromechanical and Automotive Engineering, Yantai University, China
2.School of Mechanical Engineering, Shenyang Jianzhu University, China
3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, China
4.Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, China
Recommended Citation
GB/T 7714
Yang WG,Sun LJ,Cai, Shuxiang,et al. Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces[J]. LAB ON A CHIP,2020,20(14):2447-2452.
APA Yang WG.,Sun LJ.,Cai, Shuxiang.,Chen, Yibao.,Liang WF.,...&Liu LQ.(2020).Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces.LAB ON A CHIP,20(14),2447-2452.
MLA Yang WG,et al."Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces".LAB ON A CHIP 20.14(2020):2447-2452.
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