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Recent advance in surface modification for regulating cell adhesion and behaviors
Cai SX(蔡树向)1; Wu, Chuanxiang1; Yang WG(杨文广)1; Liang WF(梁文峰)2; Yu HB(于海波)3; Liu LQ(刘连庆)3
Source PublicationNanotechnology Reviews
Indexed BySCI ; EI
EI Accession number20204609477094
WOS IDWOS:000583332300001
Contribution Rank3
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61803323, 61973224] ; Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2019BF049]
Keywordsurface modification cell adhesion cell behaviors

Cell adhesion is a basic requirement for anchorage-dependent cells to survive on the matrix. It is the first step in a series of cell activities, such as cell diffusion, migration, proliferation, and differentiation. In vivo, cells are surrounded by extracellular matrix (ECM), whose physical and biochemical properties and micromorphology may affect and regulate the function and behavior of cells, causing cell reactions. Cell adhesion is also the basis of communication between cells and the external environment and plays an important role in tissue development. Therefore, the significance of studying cell adhesion in vitro has become increasingly prominent. For instance, in the field of tissue engineering and regenerative medicine, researchers have used artificial surfaces of different materials to simulate the properties of natural ECM, aiming to regulate the behavior of cell adhesion. Understanding the factors that affect cell behavior and how to control cell behavior, including cell adhesion, orientation, migration, and differentiation on artificial surfaces, is essential for materials and life sciences, such as advanced biomedical engineering and tissue engineering. This article reviews various factors affecting cell adhesion as well as the methods and materials often used in investigating cell adhesion.

WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Funding ProjectNational Natural Science Foundation of China[61803323] ; National Natural Science Foundation of China[61973224] ; Natural Science Foundation of Shandong Province[ZR2019BF049]
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYang WG(杨文广)
Affiliation1.Department of Robotics Engineering, School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China
2.Department of Mechanical and Electronic Engineering, School of Mechanical Engineering, Shenyang Jianzhu University, Shenyang 110016, China
3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
Recommended Citation
GB/T 7714
Cai SX,Wu, Chuanxiang,Yang WG,et al. Recent advance in surface modification for regulating cell adhesion and behaviors[J]. Nanotechnology Reviews,2020,9(1):971-989.
APA Cai SX,Wu, Chuanxiang,Yang WG,Liang WF,Yu HB,&Liu LQ.(2020).Recent advance in surface modification for regulating cell adhesion and behaviors.Nanotechnology Reviews,9(1),971-989.
MLA Cai SX,et al."Recent advance in surface modification for regulating cell adhesion and behaviors".Nanotechnology Reviews 9.1(2020):971-989.
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