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Peak force tapping atomic force microscopy for advancing cell and molecular biology
Li M(李密)1,2,3; Liu LQ(刘连庆)1,2,3
Department机器人学研究室
Source PublicationNANOSCALE
ISSN2040-3364
2021
Volume13Issue:18Pages:8358-8375
Indexed BySCI ; EI
EI Accession number20212110389393
WOS IDWOS:000645254600001
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61922081, 61873258, 61925307] ; Key Research Program of Frontier Sciences CAS [ZDBS-LY-JSC043] ; Youth Innovation Promotion Association CAS [2017243] ; LiaoNing Revitalization Talents Program [XLYC1907072] ; Instrument Developing Project of the Chinese Academy of Sciences [YJKYYQ20180027]
Abstract

The advent of atomic force microscopy (AFM) provides an exciting tool to detect molecular and cellular behaviors under aqueous conditions. AFM is able to not only visualize the surface topography of the specimens, but also can quantify the mechanical properties of the specimens by force spectroscopy assay. Nevertheless, integrating AFM topographic imaging with force spectroscopy assay has long been limited due to the low spatiotemporal resolution. In recent years, the appearance of a new AFM imaging mode called peak force tapping (PFT) has shattered this limit. PFT allows AFM to simultaneously acquire the topography and mechanical properties of biological samples with unprecedented spatiotemporal resolution. The practical applications of PFT in the field of life sciences in the past decade have demonstrated the excellent capabilities of PFT in characterizing the fine structures and mechanics of living biological systems in their native states, offering novel possibilities to reveal the underlying mechanisms guiding physiological/pathological activities. In this paper, the recent progress in cell and molecular biology that has been made with the utilization of PFT is summarized, and future perspectives for further progression and biomedical applications of PFT are provided.

Language英语
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS KeywordLIVING CELLS ; MECHANICAL CHARACTERIZATION ; STAPHYLOCOCCUS-AUREUS ; MEMBRANE-PROTEINS ; NATIVE PROTEINS ; AFM ; CANCER ; MICROVILLI ; STIFFNESS ; BINDING
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Funding ProjectNational Natural Science Foundation of China[61922081] ; National Natural Science Foundation of China[61873258] ; National Natural Science Foundation of China[61925307] ; Key Research Program of Frontier Sciences CAS[ZDBS-LY-JSC043] ; Youth Innovation Promotion Association CAS[2017243] ; LiaoNing Revitalization Talents Program[XLYC1907072] ; Instrument Developing Project of the Chinese Academy of Sciences[YJKYYQ20180027]
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/28869
Collection机器人学研究室
Corresponding AuthorLi M(李密); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110169, China
3.University of Chinese Academy of Sciences, Beijing 100049, China
Recommended Citation
GB/T 7714
Li M,Liu LQ. Peak force tapping atomic force microscopy for advancing cell and molecular biology[J]. NANOSCALE,2021,13(18):8358-8375.
APA Li M,&Liu LQ.(2021).Peak force tapping atomic force microscopy for advancing cell and molecular biology.NANOSCALE,13(18),8358-8375.
MLA Li M,et al."Peak force tapping atomic force microscopy for advancing cell and molecular biology".NANOSCALE 13.18(2021):8358-8375.
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