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Non-invasive acquisition of mechanical properties of cells via passive microfluidic mechanisms: A review
Li, Zhenghua; Yang XL(杨谢柳); Zhang, Qi; Yang WG(杨文广); Zhang, Hemin; Liu LQ(刘连庆); Liang WF(梁文峰)
Department机器人学研究室
Source PublicationBIOMICROFLUIDICS
ISSN1932-1058
2021
Volume15Issue:3Pages:1-22
Indexed BySCI ; EI
EI Accession number20212510527302
WOS IDWOS:000661213300001
Contribution Rank4
Funding OrganizationNational Natural Science Foundation of China (NNSFC)National Natural Science Foundation of China (NSFC) [61973224, 61925307, 61803323] ; Natural Science Foundation of Liaoning ProvinceNatural Science Foundation of Liaoning Province [2019-KF-01-15, 2019-ZD-0673]
Abstract

The demand to understand the mechanical properties of cells from biomedical, bioengineering, and clinical diagnostic fields has given rise to a variety of research studies. In this context, how to use lab-on-a-chip devices to achieve accurate, high-throughput, and non-invasive acquisition of the mechanical properties of cells has become the focus of many studies. Accordingly, we present a comprehensive review of the development of the measurement of mechanical properties of cells using passive microfluidic mechanisms, including constriction channel-based, fluid-induced, and micropipette aspiration-based mechanisms. This review discusses how these mechanisms work to determine the mechanical properties of the cell as well as their advantages and disadvantages. A detailed discussion is also presented on a series of typical applications of these three mechanisms to measure the mechanical properties of cells. At the end of this article, the current challenges and future prospects of these mechanisms are demonstrated, which will help guide researchers who are interested to get into this area of research. Our conclusion is that these passive microfluidic mechanisms will offer more preferences for the development of lab-on-a-chip technologies and hold great potential for advancing biomedical and bioengineering research studies.

Language英语
WOS SubjectBiochemical Research Methods ; Biophysics ; Nanoscience & Nanotechnology ; Physics, Fluids & Plasmas
WOS KeywordRED-BLOOD-CELLS ; ATOMIC-FORCE MICROSCOPY ; HIGH-THROUGHPUT ; MICROPIPETTE ASPIRATION ; VISCOELASTIC PROPERTIES ; BIOLOGICAL CELLS ; QUANTITATIVE MEASUREMENTS ; ELECTRICAL MEASUREMENT ; ELASTIC-MODULUS ; TRANSIT-TIME
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other Topics ; Physics
Funding ProjectNational Natural Science Foundation of China (NNSFC)[61973224] ; National Natural Science Foundation of China (NNSFC)[61925307] ; National Natural Science Foundation of China (NNSFC)[61803323] ; Natural Science Foundation of Liaoning Province[2019-KF-01-15] ; Natural Science Foundation of Liaoning Province[2019-ZD-0673]
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/29060
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆); Liang WF(梁文峰)
Affiliation1.School of Mechanical Engineering, Shenyang Jianzhu University, Shenyang 110168, China
2.School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China
3.Department of Neurology, The People’s Hospital of Liaoning Province, Shenyang 110016, China
4.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
Recommended Citation
GB/T 7714
Li, Zhenghua,Yang XL,Zhang, Qi,et al. Non-invasive acquisition of mechanical properties of cells via passive microfluidic mechanisms: A review[J]. BIOMICROFLUIDICS,2021,15(3):1-22.
APA Li, Zhenghua.,Yang XL.,Zhang, Qi.,Yang WG.,Zhang, Hemin.,...&Liang WF.(2021).Non-invasive acquisition of mechanical properties of cells via passive microfluidic mechanisms: A review.BIOMICROFLUIDICS,15(3),1-22.
MLA Li, Zhenghua,et al."Non-invasive acquisition of mechanical properties of cells via passive microfluidic mechanisms: A review".BIOMICROFLUIDICS 15.3(2021):1-22.
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